Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1612 | Thyroid (non-cancer) | ICEECE2012

MicroRNA expression profile helps to distinguish benign and malignant thyroid nodules starting from cells of fine needle aspiration

Agretti P. , Ferrarini E. , Rago T. , Candelieri A. , De Marco G. , Dimida A. , Niccolai F. , Molinaro A. , Di Coscio G. , Pinchera A. , Vitti P. , Tonacchera M.

Objective: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that pair with target messengers regulating gene expression. They are involved in biological processes including development, organogenesis, tissue differentiation, cell cycle and metabolism. Changes in miRNA levels occur in human cancers, including thyroid cancer. Fine needle aspiration (FNA) with cytologic evaluation is the most reliable tool for malignancy prediction in thyroid nodules, but cytologic diagnos...